Both Long And Short Sleep Duration Linked To Liver Disease

Research has identified an association between abnormal sleep duration and increased risk of chronic liver disease, suggesting that sleep patterns may play a role in liver health alongside established metabolic risk factors. Sleep duration has been linked to cardiometabolic health, obesity, and insulin resistance, all of which are recognized contributors to chronic liver disease. However, its direct relationship with liver outcomes has been less well defined. The new analysis examined whether habitual sleep patterns were associated with markers of liver injury and fibrosis in adults. Researchers focused on both short and long sleep duration, as both extremes have been associated with adverse metabolic outcomes in previous studies. Participants who reported consistently short sleep duration were more likely to have elevated liver enzymes and higher fibrosis risk scores compared with those reporting moderate sleep duration. Long sleep duration was also associated with adverse liver markers, though the relationship was weaker than that observed for short sleep. poor sleep may influence liver health through multiple mechanisms, including altered glucose metabolism, increased inflammation, and disruption of circadian rhythms that regulate hepatic function The findings support growing interest in lifestyle factors beyond diet and physical activity in the prevention of chronic liver disease. Clinicians may wish to consider sleep habits as part of holistic risk assessment, particularly in patients with metabolic dysfunction-associated steatotic liver disease or other chronic liver conditions. While the study did not establish causality, it highlighted sleep as a potentially modifiable factor that could be addressed alongside established lifestyle interventions.

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